PN and PDRN: Everything You Need To Know!

Skin rejuvenation is a concept everyone has heard of, but very few know about its treatment. There are many types of treatments and therapies for skin rejuvenation, but over the past year, a new treatment has gone viral. The popularity of this treatment can be seen in the fact that many celebrities have started to endorse it, and skin booster companies have gone wild to promote its benefits for all skins.

Rejuran Healer is a well-known treatment that has received massive popularity within one year. People are not getting enough of it, and it’s on everyone’s mind these days. This treatment is also commonly referred to as Rejuran Healer, PN, or PDRN Therapy, and it has been a viral sensation since the time it was officially made public.

What is the Rejuran Healer Treatment anyway?

In simple terms, it’s a skin treatment made from biological molecules known as polynucleotides (PN). The PN molecule comprises at least thirteen nucleotide monomers that bond together. Nucleotides, you know, are structural units that make DNA. So, the DNA extracted in this treatment comes from a fish, salmon. Once collected, it gets fragmented into the PN. But how does this treatment work?

There are two effects achieved in this treatment:

1. It is the healing of wounds – by stimulating the growth factors and increasing microcirculation.
2. Anti-inflammatory – done by scavenging the free radicals and blocking the inflammatory cytokines within the body.

What is the mechanism behind Rejuran?

• PN / PDRN works by biologically increasing the metabolic activity of skin cells called fibroblasts – skin fibroblasts get stimulated to change important skin components lost while aging, such as collagen and glycosaminoglycans. and glycoproteins. To explain this in simple words, PN stimulates the older cells to function younger and work again.

• PN / PDRN mechanically act as a scaffold for cell growth and extracellular matrix – they have a 3-dimensional structure that fibroblasts can use to influence their transformation effects and achieve the needed results.

• PN / PDRN supplies the building blocks for DNA synthesis. With these salvage pathways, the PN gets further broken down by body processes into purines and pyrimidines, and later it’s recycled into a unique DNA.

PN and PDRN: What’s The Difference?

PN is a purer and more concentrated form of PDRN and has more robust regenerative properties. PN in Rejuran gets extracted from Salmon DNA, which is known to have excellent biocompatibility with human skin without any immune response, thus making this skin rejuvenation treatment highly suitable for the majority.

Many studies have focused on PDRN. Studies have shown that PDRN can help treat diabetes-related injuries and foot ulcers. In studies in animals and vitro, PDRN helps heal wounds, prevent wounds and even revitalize dead skin tissues. It is by stimulating the A2A adenosine receptor (A2A agonist).

Why use Salmon DNA for skin rejuvenation?

A study examining the effect of salmon DNA removal on human skin was published in March 2010. The research showed excellent results after the treatment; the subjects experienced drastic skin elasticity, texture, and hydration changes.

Rejuran uses salmon DNA because it is very similar to human DNA. The researchers also found that salmon DNA is very safe and compatible with the human body without causing any side effects. The salmon DNA used by Rejuran is purified so that there are no other substances, such as egg whites, that could trigger a resistance reaction. 

What are the benefits of using Rejuran treatment?

Based on a study, there are several benefits that people enjoy after using this treatment:

• Skin elasticity is enhanced.
• Hydration is improved.
• Fine lines and wrinkles will minimize.
• Skin will repair by improving the skin barrier.
• Skin will get thick, and it starts to produce oil
• Skin tone and texture are improved

What conditions can people get rid of through PN and PDRN treatment?

With this treatment, you can solve the problem of:

• Dark eye circles
• Enlarged pores
• Dullness in skin
• Stretch Marks
• Scars

What is the process of treatment in PN and PDRN?

The local anesthetic cream gets applied to the skin for 20 minutes. The doctor will then use a thin needle to inject a small amount of Rejuran Healer into your skin. The treatment lasts about 10 minutes, and you can also use it with various helping elements such as LED light to soothe the skin and reduce redness and inflammation.

What to expect after the treatment?

Because Rejuran Healer is a skin healing procedure, it takes about four weeks for you to see any visible improvement on your skin – this is because it takes about four weeks for PDRN to work and heal. The treatment is best performed three to four times with an interval of two to four weeks. The best results are visible only after the last session. After that, you can repeat the treatment every six-nine month to continue.

It would be best to remember that it’s not a facial supplement with dermal fillers, so you will not see any visible results. To take full advantage of this treatment, doctors say to complete the skin repair program in three sessions for about four weeks. It will help get the results for a longer time.

How to compare Rejuran Healer with SkinBoosters?

PN and PDRN treatments are often compared with skin booster techniques, but in reality, they are very different. Both Skinboosters and Rejuran Healer serve the same way, but they have other functions and work differently.

SkinBoosters use dermal fillers with hyaluronic acid to ensure deep hydration of the dermis. After this treatment, the skin is smoother in appearance and white in nature, which reduces the appearance of fine lines.

In the Rejuran Healer treatment, the aggressive anti-aging approach is used. It actively repairs and repairs damaged skin cells and replicated signs of aging to keep the skin young and healthy. Based on a comparative study, Rejuran offers increased fibroblast activity and increases collagen production; it helps with better skin elasticity and greater skin thickness.

Here’s a comparison of differences between these two treatments:

To conclude, SkinBoosters and Rejuran Healer treatments are very different in addressing aging and promoting skin regeneration. Combining these two treatments can achieve better anti-aging and anti-rejuvenating effects.

What are some of the best PN / PDRN products?

H-DNA	The H-DNA 0.5% by Celesta Pro offers a powerful solution effect from 2 highly active components within the healing and rejuvenating of the skin. The salmon DNA boosts cell and derma regeneration, and hyaluronic acid makes the skin soft and removes wrinkles. When the process is over, you will have smooth and elastic skin.
S-DNA	Are you looking to regenerate your cells? S-DNA 0.2% is your answer! You can refresh your skin and reverse the aging process through it. S-DNA is a cell regenerating DNA process taken from salmon fish known for repairing its damaged and aging skin. The S-DNA is injected directly within your epidermis, where it gradually starts to recover and revive your skin.
Revitalex (Injection)	This is a stimulation of angiogenesis and improvement in the blood flow. The PDRN induces the vascular endothelial cell growth factor, which results in angiogenesis and enhancement of blood flow. PDRN creates nucleotides & nucleosides that are used while forming the DNA and helps activate the average cell proliferation and growth.

Can we combine PN / PDRN with other treatments?

Absolutely! You can do it. The Rejuran treatment works well with other therapies that address skin issues. It is advised to consult a doctor if the mixture is healthy and suitable for your skin because a small amount of mistake can lead to a complete disaster in the treatment. But, if the mixture is suitable for your skin, it will help you in improving the benefits of skin hydration, skin repair, and skin refinement. It’s a one-stop solution to all skin issues.

However, it is very important that you consult with your doctor before making any decision about mixing two treatments. Every skin has different cells and conditions which can react opposite if the doctor is unaware of your past history of any other medical condition.

What are the side effects of this treatment?

Some visible side effects may include swelling, bruising, or bumps on the skin that will last for a few days after the treatment. The treatment has been reported to react with Hyaluronic Acid (HA) fillers and cause granuloma formation. Therefore, it is advised that you do not use the PN / PDRN if you are dealing with cross-linked HA fillers. It would help if you always spoke to your doctor before buying any product from the market and carefully read the ingredients to know if they are suitable for your skin or the treatment that you want to process.

Let’s wrap it up

One of the essential points to note is that PN / PDRN, regardless of showing effective results within the medical industry, is best suited for cosmetic purposes. It’s a new phenomenon, and therefore not many studies are done so far to cover all of its aspects. There is a need for a more scientific approach to finding what can be done to ensure safety and efficiency.

More and more research is being done on this topic to testify to the authenticity of PN / PDRN and its effectiveness for human skin. It is also a fantastic treatment for hair loss control, and it can be combined with other laser treatments to ensure the restoration of hair.

One thing that we can say is the promise! It has allowed doctors to explore more options to find solutions to rejuvenate the skin damage. There are significantly fewer chances that it will be replacing other treatments such as lasers or UItherapy. However, it will be a perfect mix with other treatments in restoring the cells and providing efficient results in anti-aging.